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For patients with severe symptoms, treatment starts with 1000 mcg injected intramuscularly once daily for 7 days, then the frequency can vary to 1-3 times weekly for 4-8 weeks

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doi: 10.4161/pri.4.2.11960 51 DisantoG.AdiutoriR.DobsonR.MartinelliV.Dalla CostaG.RuniaT.et al